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Simoa單分子免疫陣列超靈敏細胞因子
檢測服務(wù)

產(chǎn)品介紹:

SimoaTM(Single Molecular Array)又稱(chēng)作數字式ELISA,是基于Simoa HD-1數字式單分子免疫陣列分析儀,可直接對血清和血漿中蛋白、核酸等生物標志物進(jìn)行檢測的技術(shù)。它的檢測靈敏度比傳統的免疫檢測技術(shù)平均高1000倍以上,將蛋白質(zhì)檢測技術(shù)直接帶入單分子、數字化檢測時(shí)代,成為fg超低豐度蛋白質(zhì)檢測領(lǐng)域的優(yōu)勢技術(shù)。


技術(shù)原理:

1、將捕獲抗體偶聯(lián)到磁珠上,磁珠與目標抗原結合,目的抗原與檢測抗體結合并帶有梅標記。

2、洗滌磁珠以去除非特異性結合的蛋白,加入酶反應底物。

3、將加入底物的磁珠轉入Simoa光盤(pán)上,將熒光信號封閉在小孔內。

 

應用領(lǐng)域:

Simoa技術(shù)可用于腫瘤、神經(jīng)、感染性疾病、免疫炎癥、miRNA檢測,特別是癌癥的早期檢測、術(shù)后的監測和精準用藥,將極大推動(dòng)精準醫療的發(fā)展。運用Simoa可檢測到的低濃度生物標志物進(jìn)行準確分析,為生命科學(xué)研究、體外診斷、伴隨診斷和血液篩查等領(lǐng)域。目前在全球引用該技術(shù)發(fā)表的文獻有200多篇,包括高分雜志Nature, Nature Biotechnology, JEM, JAMA Neurology等。

參考文獻

[1] Gill J, Merchant-Borna K, Jeromin A, et al. Acute plasma tau relates to prolonged return to play after concussion[J]. Neurology, 2017, 88: 595-602.

[2] Lin YS, Lee WJ, Wang SJ, et al. Levels of plasma neuroflament light chain and cognitive function in patients with Alzheimer or Parkinson disease[J],2018, Science Report, 2018, 8: 018-35766.

[3] Sokoll LJ, Zhang Z, Chan DW, et al. Do Ultrasensitive Prostate Specifc Antigen Measurements Have a Role in Predicting Long-Term Biochemical Recurrence-Free Survival in Men after Radical Prostatectomy?[J]. Journal of Urology, 2016, 195: 330-336.

[4] Byrne LM, Rodrigues FB, Blennow K, et al. Neuroflament light protein in blood as a potential biomarker of neurodegeneration in Huntington's disease: a retrospective cohort analysis[J]. Lancet Neurology, 2017, 16: 601-609.

[5] Mattsson N, Andreasson U, Zetterberg H,(2017) Association of Plasma Neuroflament Light With Neurodegeneration in Patients With Alzheimer Disease[J]. JAMA Neurology, 2017, 74: 557-566.

[6] Piehl F, Kockum I, Khademi M, et al. Plasma neuroflament light chain levels in patients with MS switching from injectable therapies to fngolimod[J]. Multiple Sclerosis Journal, 2018, 24: 1046-1054.

[7] Hansson O, Janelidze S, Hall S, et al. (2017) Blood-based NfL: A biomarker for differential diagnosis of parkinsonian disorder[J]. Neurology, 2017, 88: 930-937.

[8] Chen Z, Mengel D, Keshavan A, et al. Learnings about the complexity of extracellular tau aid development of a blood-based screen for Alzheimer's disease[J]. Alzheimers Dement, 2018, 9: 33561-33561.

[9] Yanamandra K, Patel TK, Jiang H, et al. Anti-tau antibody administration increases plasma tau in transgenic mice and patients with tauopathy[J]. Science Translation Medicine. 2017, 9 (386):eaal2029.

[10] Kawata K, Mitsuhashi M, Aldret R. A Preliminary Report on Brain-Derived Extracellular Vesicle as Novel Blood Biomarkers for Sport-Related Concussions[J]. Frontiers Neurology, 2018, 9:239.


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